JAML overexpressed in colorectal cancer promotes tumour proliferation by activating the PI3K-AKT-mTOR signalling pathway.

ABSTRACT: The expression and biological function of junctional adhesion molecule-like protein (JAML) in colorectal cancer (CRC) remain unclear. Paraffin tissue samples from 50 cases of CRC were collected to determine the expression of JAML. JAML was overexpressed or knock-down in CRC cells to evaluated the proliferation, migration and invasion in vitro and in vivo. Western-blot and others were applied to explore the mechanisms. The study showed that JAML was highly expressed within cancer tissues in 50% (25/50) of patients with CRC, and was correlated with higher TNM stage (p < 0.05). Patients of JAML^-high group had poorer overall survival compared to JAML^-low group (p = 0.0362, HR = 0.4295, 95% CI of 0.1908-0.9667). The tumour infiltrating lymphocytes (TILs) was lower in the J

SUBMITTER: Fang Y 

PROVIDER: S-EPMC11489459 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature