Building multiscale models with PhysiBoSS, an agent-based modeling tool.

ABSTRACT: Multiscale models provide a unique tool for analyzing complex processes that study events occurring at different scales across space and time. In the context of biological systems, such models can simulate mechanisms happening at the intracellular level such as signaling, and at the extracellular level where cells communicate and coordinate with other cells. These models aim to understand the impact of genetic or environmental deregulation observed in complex diseases, describe the interplay between a pathological tissue and the immune system, and suggest strategies to revert the diseased phenotypes. The construction of these multiscale models remains a very complex task, including the choice of the components to consider, the level of details of the processes to simulate, or the fitting o

SUBMITTER: Ruscone M 

PROVIDER: S-EPMC11489466 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature