Lower Parathyroid Hormone Levels are Associated With Reduced Fracture Risk in Japanese Patients on Hemodialysis.

ABSTRACT:

Introduction

Secondary hyperparathyroidism (SHPT) affects bone metabolism and may lead to bone fragility. However, there is conflicting evidence as to whether parathyroid hormone (PTH) levels are associated with fracture risk and whether the relationship is linear or U-shaped.

Methods

We examined the association between PTH levels and the risk of any fracture and site-specific fractures in a nationwide cohort of 180,333 patients on hemodialysis. We also examined the association between the percent change in PTH levels during the preceding 1 year and subsequent fracture.

Results

At baseline, the median intact PTH level was 141 pg/ml (interquartile range, 78-226 pg/ml). During 1 year of follow-up, there were a total of 3762 fractures requiring hospitalization (1361 hip,

SUBMITTER: Komaba H 

PROVIDER: S-EPMC11489479 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature