Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice.

ABSTRACT: Monocytes directly contribute to atherosclerosis development by their recruitment to plaques in which they differentiate into macrophages. In the present study, we ask how modulating monocyte glucose metabolism could affect their homeostasis and their impact on atherosclerosis. Here we investigate how circulating metabolites control monocyte behavior in blood, bone marrow and peripheral tissues of mice. We find that serum glucose concentrations correlate with monocyte numbers. In diet-restricted mice, monocytes fail to metabolically reprogram from glycolysis to fatty acid oxidation, leading to reduced monocyte numbers in the blood. Mechanistically, Glut1-dependent glucose metabolism helps maintain CD115 membrane expression on monocytes and their progenitors, and regulates monocyte migrator

SUBMITTER: Gallerand A 

PROVIDER: S-EPMC11489573 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature