Pallidal and Thalamic Deep Brain Stimulation in the Treatment of Unilateral Dystonia: A Prospective Assessment.

ABSTRACT:

Background

The complexities of unilateral dystonia have led to exploring simultaneous (dual) globus pallidus internus (GPi) and motor ventral thalamus (Vim/Vop) deep brain stimulation (DBS), yet detailed assessments are lacking.

Objectives

To assess the efficacy of GPi, Vim/Vop, and dual DBS in unilateral dystonia.

Methods

Three patients with unilateral dystonia (two idiopathic, one acquired), implanted with two DBS electrodes targeting ipsilateral Vim/Vop and GPi, were included. Three stimulation modalities were assessed. First, one electrode was activated, then the other, and finally, both electrodes were activated simultaneously.

Results

DBS yielded substantial symptomatic reductions in all three evaluated stimulation modalities. Patients exhibited varying r

SUBMITTER: Altamirano JM 

PROVIDER: S-EPMC11489622 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature