The accordion technique did not improve bone healing in a mouse model of distraction osteogenesis.

ABSTRACT: Distraction osteogenesis (DO) is a valuable surgical method for limb lengthening and bone defect correction, but its lengthy consolidation phase presents challenges. The accordion technique (AT), involving compression and distraction of bone segments, has shown potential for enhancing healing. This study aimed to investigate the effectiveness of the AT conducted at three different time points (distraction phase, early consolidation phase, or late consolidation phase) compared to conventional DO in a mouse osteotomy model. Healing was evaluated using in vivo microCT, histology, and computational modeling. Results showed that bridging frequency, BV, and callus tissue composition were similar between conventional DO and late consolidation AT. In contrast, distraction phase AT led to delayed h

SUBMITTER: Bertrand DT 

PROVIDER: S-EPMC11489654 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature