The alternative splicing landscape of infarcted mouse heart identifies isoform level therapeutic targets.

ABSTRACT: Alternative splicing is an important process that contributes to highly diverse transcripts and protein products, which can affect the development of disease in various organisms. Cardiovascular disease (CVD) represents one of the greatest global threats to humans, particularly acute myocardial infarction (MI) and subsequent ischemic reperfusion (IR) injury, which involve complex transcriptomic changes in heart tissues associated with metabolic reshaping and immunological response. In this study, we used a newly developed ONT full-length transcriptomic approach and performed transcript-resolved differential expression profiling in murine models of MI and IR. We built an analytical pipeline to reliably identify and quantify alternative splicing products (isoforms), expanding on the currentl

SUBMITTER: Xia B 

PROVIDER: S-EPMC11489681 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature