Direct observation of NMR transverse relaxation in nanopatterned clusters of iron oxide particles.

ABSTRACT:

Purpose

We aim to verify predictions showing T₂ relaxation rate of nanoparticle clusters and its dependence on spacing, size, geometry, and pulse sequence.

Methods

We performed a laboratory validation study using nanopatterned arrays of iron oxide nanoparticles to precisely control cluster geometry and image diverse samples using a 4.7T MRI scanner with a T₂ -weighted fast spin-echo multislice sequence. We applied denoising and normalization to regions of interest and estimated relative R₂ for each relevant nanoparticle array or nanocluster array. We determined significance using an unpaired two-tailed t-test or one-way analysis of variance and performed curve fitting.

Results

We measured a density-dependent T₂ effect (p = 8

SUBMITTER: Bok I 

PROVIDER: S-EPMC11489851 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature