Association of hyperactivated transposon expression with exacerbated immune activation in systemic lupus erythematosus.

ABSTRACT:

Background

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder, and transposable elements (TEs) have been hypothesized to play a significant role in its development. However, limited research has explored this connection. Our study aimed to examine the relationship between TE expression and SLE pathogenesis.

Methods

We analyzed whole blood RNA-seq datasets from 198 SLE patients and 84 healthy controls. The REdiscoverTE pipeline was employed to quantify TE and other gene expressions, identifying differentially expressed TEs. A TE score was calculated to measure overall TE expression for each sample. Gene ontology and gene set enrichment analyses were conducted to explore the functional implications of TE upregulation. Independent datasets were utilized to repl

SUBMITTER: Wang FQ 

PROVIDER: S-EPMC11490001 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature