Zhi-Kang-Yin formula attenuates high-fat diet-induced metabolic disorders through modulating gut microbiota-bile acids axis in mice.

ABSTRACT:

Background

Metabolic disorders have become one of the global medical problems. Due to the complexity of its pathogenesis, there is still no effective treatment. Bile acids (BAs) and gut microbiota (GM) have been proved to be closely related to host metabolism, which could be important targets for metabolic disorders. Zhi-Kang-Yin (ZKY) is a traditional Chinese medicine (TCM) formula developed by the research team according to theory of TCM and has been shown to improve metabolism in clinic. However, the underlying mechanisms are unclear.

Aim of the study

This study aimed to investigate the potential mechanisms of the beneficial effect of ZKY on metabolism.

Methods

High-fat diet (HFD)-fed mice were treated with and without ZKY. The glucose and lipid metabolism-related

SUBMITTER: Li Y 

PROVIDER: S-EPMC11490013 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature