DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise.

ABSTRACT:

Background

DNA methylation profiling may provide a more accurate measure of the smoking status than self-report and may be useful in guiding clinical interventions and forensic investigations. In the current study, blood DNA methylation profiles of nearly 800 Polish individuals were assayed using Illuminia EPIC and the inference of smoking from epigenetic data was explored. In addition, we focused on the role of the AHRR gene as a top marker for smoking and investigated its responsiveness to other lifestyle behaviors.

Results

We found > 450 significant CpGs associated with cigarette consumption, and overrepresented in various biological functions including cell communication, response to stress, blood vessel development, cell death, and atherosclerosis. The model consisting

SUBMITTER: Pospiech E 

PROVIDER: S-EPMC11490037 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature