Fecal glycoprotein 2 is a marker of gut microbiota dysbiosis and systemic inflammation.

ABSTRACT:

Background

Antimicrobial autoantigenic glycoprotein 2 (GP2) is an important component of the innate immune system which originates from the exocrine pancreas as well as from the small intestines. The relationship of GP2 with the intestinal microbiome as well as the systemic implications of increased fecal GP2 levels are, however, still unclear. Therefore, fecal samples from 2,812 individuals of the Study of Health in Pomerania (SHIP) were collected to determine GP2 levels (enzyme-linked immunosorbent assay) and gut microbiota profiles (16 S rRNA gene sequencing). These data were correlated and associated with highly standardised and comprehensive phenotypic data of the study participants.

Results

Fecal GP2 levels were increased in individuals with higher body mass index and

SUBMITTER: Frost F 

PROVIDER: S-EPMC11490104 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature