Altered RBC deformability in diabetes: clinical characteristics and RBC pathophysiology.

ABSTRACT:

Background

Reduced red blood cell deformability (RBCD) is associated with diabetic vascular complications, but early pathophysiological RBC changes and predictive demographic and clinical factors in populations with diabetes are unclear. An understanding of early diabetes-specific RBC changes associated with impaired RBCD is essential in investigating mechanisms that predispose to diabetic vascular complications.

Methods

We conducted an outpatient cross-sectional study of participants in a well-controlled diabetes cohort (N81) and nondiabetic controls (N78) at the National Institutes of Health. First, between-group differences in RBCD measures were assessed with shear stress-gradient ektacytometry. Differences in structural RBC parameters were assessed using osmotic gradient

SUBMITTER: Ebenuwa I 

PROVIDER: S-EPMC11490132 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature