Effects of 6-week olanzapine treatment on serum IL-2, IL-4, IL-8, IL-10, and TNF-α levels in drug-naive individuals with first-episode schizophrenia.

ABSTRACT:

Background

Schizophrenia is a complex neuropsychiatric disorder. Growing evidence indicates that the activation of the inflammatory response system with interleukin (IL)-2, IL-4, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α) plays an important role in the pathogenesis of schizophrenia,. However, clinical data on cytokine levels in patients with schizophrenia treated with antipsychotics are inconsistent or inconclusive. In this study, we have examined inflammatory factors' alterations and their relationship to changes in clinical symptoms before and after olanzapine treatment of drug-naive patients with first-episode schizophrenia.

Methods

We recruited 142 hospitalized patients with first-episode schizophrenia as a study group; blood samples were collected, and the pat

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11490170 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature