Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.

ABSTRACT: The subregions of the entorhinal cortex (EC) are conventionally thought to compute dichotomous representations for spatial processing, with the medial EC (MEC) providing a global spatial map and the lateral EC (LEC) encoding specific sensory details of experience. Yet, little is known about the specific types of information EC transmits downstream to the hippocampus. Here, we exploit in vivo sub-cellular imaging to record from EC axons in CA1 while mice perform navigational tasks in virtual reality (VR). We uncover distinct yet overlapping representations of task, location, and context in both MEC and LEC axons. MEC transmitted highly location- and context-specific codes; LEC inputs were biased by ongoing navigational goals. However, during tasks with reliable reward locations, the animals

SUBMITTER: Bowler JC 

PROVIDER: S-EPMC11490304 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature