Parkinson's Disease Gene Screening in Familial Cases from Central and South America.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most common neurodegenerative disease following Alzheimer's disease. Nearly 30 causative genes have been identified for PD and related disorders. However, most of these genes were identified in European-derived families, and little is known about their role in Latin American populations.

Objectives

Our goal was to assess the spectrum and frequency of pathogenic variants in known PD genes in familial PD patients from Latin America.

Methods

We selected 335 PD patients with a family history of PD from the Latin American Research Consortium on the Genetics of PD. We capture-sequenced the coding regions of 26 genes related to neurodegenerative parkinsonism. Of the 335 PD patients, 324 had sufficient sequencing coverage to b

SUBMITTER: Lorenzo-Betancor O 

PROVIDER: S-EPMC11490405 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature