The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits.

ABSTRACT: Iron is an essential mineral that supports numerous biological functions. Studies have reported associations between iron dysregulation and certain cardiovascular and neurodegenerative diseases, but the direction of influence is not clear. Our goal was to use computational approaches to better understand the role of genetically predicted iron levels on disease risk. We meta-analyzed genome-wide association study summary statistics for serum iron levels from two cohorts and two previous meta-analyses. We then obtained summary statistics from 11 neurodegenerative, cerebrovascular, cardiovascular or lipid traits to assess global and regional genetic correlation between iron levels and these traits. We used two-sample Mendelian randomization (MR) to estimate causal effects. Sex-stratified anal

SUBMITTER: Belbellaj W 

PROVIDER: S-EPMC11490554 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature