Hippocampal recording with a soft microelectrode array in a cranial window imaging scheme: a validation study.

ABSTRACT: The hippocampus has a crucial role in the formation, consolidation and recall of memories as well as in navigation related processes. These functions are in the focus of neuroscience and different disciplines have contributed to this research field for decades. Two-photon imaging in awake animals is a valuable new aspect for these observations, especially when it is supported by electrophysiology. In this study, we applied high speed two-photon hippocampal imaging through a chronically implanted, soft, transparent microelectrode (STM) device incorporated into a cranial window chamber in awake mice. We monitored the impedance of the recording sites over the course of the experiments to observe long-term changes in recording quality. The large-scale ipsilateral local field potential (LFP) re

SUBMITTER: Juhasz G 

PROVIDER: S-EPMC11490575 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature