Isolation of holostane-type saponins from the black sea cucumber <i>Holothuria atra</i> and evaluating their anti-allergic activity: in vitro and in silico study.

ABSTRACT: Sea cucumbers are both versatile marine organisms and an Asian marine food known to have several medicinal effects. We evaluated the anti-allergic potential of some major purified holostane-type saponins from the body wall of the black sea cucumber, Holothuria atra. Six saponin compounds were isolated, holothurin B (1), holothurin A (2), 24-dehydro echinoside A (3), desholothurin A1 (4), desholothurin A (5), and des 24-dehydro echinoside A (6). The structures were identified based on spectroscopic methods and by comparison with the literature. Each compound's inhibitory activity toward the release of β-hexosaminidase was evaluated. Among the six compounds, holothurin B (1) showed the strongest inhibition of the degranulation at all te

SUBMITTER: Elkattan A 

PROVIDER: S-EPMC11490590 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature