Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs.

ABSTRACT: The exploration of artificial metal-peptide assemblies (MPAs) is one of the most exciting fields because of their great potential for simulating the dynamics and functionality of natural proteins. However, unfavorable enthalpy changes make forming discrete complexes with large and adaptable cavities from flexible peptide ligands challenging. Here, we present a strategy integrating metal-cluster building blocks and peptides to create chiral metal-peptide assemblies and get a family of enantiopure [R-/S-Ni₃L₂]_n (n = 2, 3, 6) MPAs, including the R-/S-Ni₆L₄ capsule, the S-Ni₉L₆ trigonal prism, and the R-/S-Ni₁₈L₁₂ octahedron cage. X-ray crystallography shows MPA formation reactions are highly sol

SUBMITTER: Cheng PM 

PROVIDER: S-EPMC11490616 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature