Impaired SARS-CoV-2-specific responses via activated T follicular helper cells in immunocompromised kidney transplant recipients.

ABSTRACT: Activated T follicular helper (aTfh) cells are likely important in host immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. We characterized the immune responses of aTfh cells to the second (D2) and third (booster; D3) doses of an mRNA vaccine in the peripheral blood of 40 kidney transplant recipients (KTRs) and 17 healthy control volunteers (HCs). A significant increase in SARS-CoV-2-specific IgG antibody was seen after D3 in the KTRs; nonetheless, the levels after D2 and D3 were significantly lower than in the HCs. After D2, dramatic increases in activated CD45RA^-CXCR5⁺ICOS⁺PD1⁺ circulating Tfh (acTfh) cells were observed in the HCs, as well as the seropositive patients among the KTRs, when compare

SUBMITTER: Tomita Y 

PROVIDER: S-EPMC11490627 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature