ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-β signaling cascade.

ABSTRACT: Morphogens play a critical role in coordinating stress adaptation and aging across tissues, yet their involvement in neuronal mitochondrial stress responses and systemic effects remains unclear. In this study, we reveal that the transforming growth factor beta (TGF-β) DAF-7 is pivotal in mediating the intestinal mitochondrial unfolded protein response (UPR^mt) in Caenorhabditis elegans under neuronal mitochondrial stress. Two ASI sensory neurons produce DAF-7, which targets DAF-1/TGF-β receptors on RIM interneurons to orchestrate a systemic UPR^mt response. Remarkably, inducing mitochondrial stress specifically in ASI neurons activates intestinal UPR^mt, extends lifespan, enhances pathogen resistance, and reduces both brood size and body fat levels. Furthermor

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11490647 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature