Chongrenside D from Smilax china L protects against inflammation-induced joint destruction via inhibiting osteoclastogenesis.

ABSTRACT:

Background

Bone-destructive diseases including rheumatoid arthritis (RA), osteoporosis, and bone metastases, are increasingly prevalent and worrisome due to the over-activated of osteoclasts. Chongrenside D (CGD) is a furostanol saponin extracted from Smilax china L, which has been demonstrated to have anti-inflammatory properties in our previous research. However, its effect on rheumatoid arthritis, especially on osteoclast differentiation and bone destruction has not yet been investigated.

Methods

We evaluated the toxicity of CGD on the cell we used, RANKL-induced osteoclast formation, bone resorption activity, and osteoclast-specific genes or protein expression using bone marrow-derived monocytes (BMMs) -derived osteoclasts. Furthermore, the protective function of CGD on

SUBMITTER: Liang Y 

PROVIDER: S-EPMC11490767 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature