ANXA3 as a novel biomarker for sepsis diagnosis: Evidence from integrative WGCNA analysis.

ABSTRACT: Sepsis is a dysregulated immune response to infection that comes with multiple organ dysfunction and high mortality. The management of sepsis relies heavily on early recognition and diagnosis, but current diagnostic methods have limitations in timeliness, sensitivity, and discriminability. This study aims to discover novel biomarkers for sepsis diagnosis. Four datasets from different regions were analyzed using weighted gene co-expression network analysis (WGCNA), and genes with high Gene Significance values across these datasets were overlapped. Finally, two genes, CD177 and ANXA3, were identified. ANXA3 was validated as a potential sepsis biomarker by checking multiple datasets and Receiver Operating Characteristic (ROC) Curve Analysis. Of note, ANXA3 could di

SUBMITTER: Zhang JX 

PROVIDER: S-EPMC11490821 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature