Association of Lymphovascular Invasion with Biochemical Recurrence and Adverse Pathological Characteristics of Prostate Cancer: A Systematic Review and Meta-analysis.

ABSTRACT:

Background and objective

Lymphovascular invasion (LVI) is a significant histopathological feature in prostate cancer (PCa) associated with higher risk of biochemical recurrence (BCR) and other adverse outcomes. Our aim was to assess the association of LVI found in radical prostatectomy (RP) specimens with BCR and adverse clinicopathological findings.

Methods

A systematic literature search was conducted using the PubMed, Embase, and Web of Science databases in July 2023, with an additional search in May 2024. We included 94 prospective and retrospective studies reporting on LVI in RP specimens and its association with the specified outcomes.

Key findings and limitations

Meta-analyses revealed that LVI is significantly associated with higher BCR risk (hazard ratio 1.96,

SUBMITTER: Karwacki J 

PROVIDER: S-EPMC11490882 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature