Validation of Ethical COVID-19 Antibody Testing that Adheres to Pro-Life Principles.

ABSTRACT: We describe validation of a COVID-19 antibody test for detection of anti-SARS-CoV-2 receptor-binding domain (RBD) IgG antibodies in blood plasma utilizing ethically sourced reagents not derived from aborted fetal cell lines. The test demonstrated specificity of 100% (95% confidence intervals 77.2-100%) and sensitivity of 100% (95% confidence intervals 79.6-100%) when evaluating blood specimens previously determined to be negative (n = 13) or positive for anti-SARS-CoV-2 RBD IgG antibodies due to natural SARS-CoV-2 exposure (n = 13) or COVID-19 vaccination (n = 15). The test was used to screen 230 blood specimens from individuals with unknown SARS-CoV-2 exposure (n = 103) or that were naturally exposed to SARS-CoV-2 (n = 44), received a COVID-19 vaccine (<

SUBMITTER: McKenna KC 

PROVIDER: S-EPMC11490964 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature