SMC4 serves as a potential marker for the diagnosis and prognosis of colon adenocarcinoma.

ABSTRACT:

Objective

We aimed to explore the role of structural maintenance of chromosomes 4 (SMC4) in malignant progression and immunology of colon adenocarcinoma (COAD).

Methods

The expression, genetic and protein features, and immune cell infiltration of SMC4 in pan-cancer were provided by public databases and websites. The protein expression of SMC4 in COAD tissues was screened by immunohistochemical assay. Si-RNA-mediated transfection was performed in COAD cells and the proliferation viability was measured using MTT, colony formation and EdU assays. Cell autophagy was detected by AO staining, western blots, and immunofluorescence staining. The migratory ability was determined using scratch and transwell assays. The expression of epithelial-to-mesenchymal transition (EMT) markers a

SUBMITTER: Yang D 

PROVIDER: S-EPMC11490969 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature