Can switching from cigarettes to heated tobacco products reduce consequences of pulmonary infection?

ABSTRACT:

Rationale

While tobacco industry data suggests that switching from combustible cigarettes to heated tobacco products (HTPs), like IQOS, may reduce the users' exposure to respiratory toxicants, it is not known if using HTPs impacts the outcomes of acute respiratory infections.

Objectives

Does switching from cigarettes to HTPs improve responses to pulmonary infection.

Methods

We conducted experiments in which 3 groups of mice were pre-exposed to cigarette smoke for 8 weeks, followed by 8-week exposure to (1) HTPs (tobacco product switching), (2) air (smoking cessation), or (3) continued exposure to cigarette smoke. Pulmonary bacterial clearance and surrogate markers of lung damage were assessed as study outcomes.

Main results

Significantly compromised clearance o

SUBMITTER: Bhat TA 

PROVIDER: S-EPMC11491011 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature