Weight, habitual fibre intake, and microbiome composition predict tolerance to fructan supplementation.

ABSTRACT: Fructans are commonly used as dietary fibre supplements for their ability to promote the growth of beneficial gut microbes. However, fructan consumption has been associated with various dosage-dependent side effects. We characterised side effects in an exploratory analysis of a randomised trial in healthy adults (n = 40) who consumed 18 g/day inulin or placebo. We found that individuals weighing more or habitually consuming higher fibre exhibited the best tolerance. Furthermore, we identified associations between gut microbiome composition and host tolerance. Specifically, higher levels of Christensenellaceae R-7 group were associated with gastrointestinal discomfort, and a machine-learning-based approach successfully predicted high levels of flatulence, with [Ruminococcus

SUBMITTER: Letourneau J 

PROVIDER: S-EPMC11491164 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature