A Mendelian randomization study on causal relationship between metabolic factors and abnormal spermatozoa.

ABSTRACT:

Background

Male infertility is a global health problem. There is an increasing attention on the association of metabolic status with spermatogenesis. However, the impacts of metabolic factors on semen parameters are still unclear. To provide evidence for developing appropriate interventions on disease screening and prevention, we performed a Mendelian randomization (MR) analysis to assess causality between various metabolic factors and abnormal spermatozoa.

Methods

We conducted a two-sample MR study to appraise the causal effects of 16 metabolic factors (including indexes of metabolic traits, glucose metabolism, lipid profile, adipokines, uric acid and metabolic diseases) on abnormal spermatozoa from genome-wide association studies (GWASs). Filtering with strict criteria, el

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11491210 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature