Ferroptosis-related gene signature predicts prognosis and immune microenvironment in prostate cancer.

ABSTRACT:

Background

Ferroptosis, an iron-dependent form of programmed cell death, significantly impacts cancer, yet its link to prostate cancer (PCa) prognosis remains underexplored. This study aims to develop and validate a ferroptosis-related gene signature to predict PCa prognosis and immune microenvironment differences, potentially identifying therapeutic targets.

Methods

RNA-sequencing data of 478 PCa patients and corresponding clinical data were downloaded from The Cancer Genome Atlas (TCGA) database. We investigated the disease-free survival (DFS) rates of the high- and low-risk groups using the Kaplan-Meier method. Functional differences between the high- and low-risk groups were investigated by a gene set enrichment analysis (GSEA), and Gene Ontology (GO) and Kyoto Encyclope

SUBMITTER: Wang H 

PROVIDER: S-EPMC11491218 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature