Dural Metastasis in Breast Cancer: MRI-Based Morphological Subtypes and Their Clinical Implications.

ABSTRACT:

Purpose

This study aimed to investigate the clinical factors associated with breast cancer (BRCA) dural metastases (DMs), their impact on prognosis compared to brain parenchymal metastases (BPMs) alone, and differences between DM subtypes, aiming to inform clinical decisions.

Materials and methods

We retrospectively analyzed 119 patients with BRCA with brain metastasis, including 91 patients with BPM alone and 28 patients with DM. Univariate and multivariate analyses were performed to compare the clinical characteristics between the two groups and within subtypes of DM. Overall survival after DM (OSDM) and the interval from DM to leptomeningeal carcinomatosis (LMC) were compared using Kaplan-Meier analysis.

Results

DM was notably linked with extracranial metastasis, l

SUBMITTER: Ahn SJ 

PROVIDER: S-EPMC11491251 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature