Prognostic Significance of Bulky Nodal Disease in Anal Cancer Management: A Multi-institutional Study.

ABSTRACT:

Purpose

This study aimed to assess the prognostic significance of bulky nodal involvement in patients with anal squamous cell carcinoma treated with definitive chemoradiotherapy.

Materials and methods

We retrospectively analyzed medical records of patients diagnosed with anal squamous cell carcinoma who underwent definitive chemoradiotherapy at three medical centers between 2004 and 2021. Exclusion criteria included distant metastasis at diagnosis, 2D radiotherapy, and salvage treatment for local relapse. Bulky N+ was defined as nodes with a long diameter of 2 cm or greater.

Results

A total of 104 patients were included, comprising 51 with N0, 46 with non-bulky N+, and seven with bulky N+. The median follow-up duration was 54.0 months (range, 6.4 to 162.2 months). Est

SUBMITTER: Chun SJ 

PROVIDER: S-EPMC11491260 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature