Association between plasma trimethylamine N-oxide and coronary heart disease: new insights on sex and age differences.

ABSTRACT:

Aim

Elevated plasma trimethylamine N-oxide (TMAO) is related to atherosclerosis. Whether the relationship of TMAO and coronary heart disease (CHD) is influenced by sex or age is uncertain. We aim to explore the sex and age differences in the relationship between plasma TMAO and CHD risk and severity.

Methods

A case-control study was conducted in patients undergoing elective coronary angiography. Matched by sex, age (±2 years), and operation date (±180 days), a total of 429 CHD case-control pairs were included. Plasma TMAO was quantified using liquid chromatography-tandem mass spectrometry. Logistic regression analyses were performed to evaluate the association between plasma TMAO and CHD risk and severity.

Results

The overall median (interquartile range) plasma TMAO l

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11491342 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature