Harnessing the power of AI in precision medicine: NGS-based therapeutic insights for colorectal cancer cohort.

ABSTRACT:

Purpose

Developing innovative precision and personalized cancer therapeutics is essential to enhance cancer survivability, particularly for prevalent cancer types such as colorectal cancer. This study aims to demonstrate various approaches for discovering new targets for precision therapies using artificial intelligence (AI) on a Polish cohort of colorectal cancer patients.

Methods

We analyzed 71 patients with histopathologically confirmed advanced resectional colorectal adenocarcinoma. Whole exome sequencing was performed on tumor and peripheral blood samples, while RNA sequencing (RNAseq) was conducted on tumor samples. We employed three approaches to identify potential targets for personalized and precision therapies. First, using our in-house neoantigen calling pipeline,

SUBMITTER: Murcia Pienkowski V 

PROVIDER: S-EPMC11491396 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature