Dynamic changes of neutralizing antibody and memory T cell responses six months post Omicron XBB reinfection.

ABSTRACT:

Introduction

With the continued prevalence of COVID-19, repeated infection caused by SARS-CoV-2 has become common. However, studies on immune persistence post Omicron XBB reinfection are limited.

Methods

We prospectively studied the durability and cross-reactivity of neutralizing antibodies (NAbs) and T cell responses among 20 subjects who suffered Omicron BA.5 infection with or without Omicron XBB reinfection over 6-month through the pseudovirus neutralization test and the fluorospot assay.

Results

NAbs against EG.5.1, BA.2.86, and JN.1 subvariants were decreased and undetectable at 6-month post Omicron BA.5 infection, while those elicited by Omicron XBB reinfection were significant increased and remained detectable against all detected variants within 6-month. Furth

SUBMITTER: Zhao XJ 

PROVIDER: S-EPMC11491401 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature