Optimizing risk stratification for intermediate-risk prostate cancer - the prognostic value of baseline health-related quality of life.

ABSTRACT:

Objective

To investigate the prognostic value of baseline health-related quality of life (HRQOL) for patients with intermediate-risk localized prostate cancer (IR-PCa) undergoing radical prostatectomy (RP).

Methods

4780 patients with IR-PCa according to NCCN risk stratification were identified from a prospectively maintained database. All patients were treated with RP and had prospectively assessed baseline HRQOL. Main outcomes were oncologic endpoints metastasis-free survival (MFS); biochemical recurrence free survival (BRFS) and overall survival (OS). Multivariable Cox regression models assessed prognostic significance of baseline global health status (GHS) on survival outcomes. Harrell's discrimination C-index was applied to calculate the predictive accuracy of the model.

SUBMITTER: Westhofen T 

PROVIDER: S-EPMC11491415 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature