Low blood S-methyl-5-thioadenosine is associated with postoperative delayed neurocognitive recovery.

ABSTRACT: Elderly individuals display metabolite alterations that may contribute to development of cognitive impairment following surgery and anesthesia. However, these relationships remain largely unexplored. The study aims to assess the S-methyl-5-thioadenosine (MTA) is associated with postoperative delayed neurocognitive recovery (dNCR). We assess altered metabolites following anesthesia/surgery in both mice and patients to identify blood biomarkers of dNCR. Preoperative and postoperative plasma metabolites are determined by widely targeted metabolomics. The brains of mice with anesthesia/surgery show decreased MTA and activated MTA phosphorylase. Mice also show that preoperative administration of MTA can prevent inflammation and cognitive decline. In clinical patients, we detect lower preoperati

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11491466 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature