Metabolic modulation of melanoma enhances the therapeutic potential of immune checkpoint inhibitors.

ABSTRACT:

Introduction

Lactate is a pivotal molecule with diverse functions in the metabolic reprogramming of cancer cells. Beyond its role in metabolism, lactate exerts a modulatory effect within the tumor microenvironment; it is utilized by stromal cells and has been implicated in the suppression of the immune response against the tumor.

Methods

Using in vitro assays (including flow cytometry, live-cell imaging and metabolic analyses), the impact of lactate dehydrogenase inhibitors (LDHIs) on melanoma cells were assessed. The therapeutic potential of LDHIs with immune checkpoint inhibitors (ICIs) were tested in vivo in murine models of melanoma tumors.

Results

A potent anti-proliferative effect (via both cell cycle alterations and enhanced apoptosis) of LDHIs, O

SUBMITTER: Gurel Z 

PROVIDER: S-EPMC11491500 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature