Characterization and trans-generation dynamics of mitogene pool in the silver carp (Hypophthalmichthys molitrix).

ABSTRACT: Multicopied mitogenome are prone to mutation during replication often resulting in heteroplasmy. The derived variants in a cell, organ, or an individual animal constitute a mitogene pool. The individual mitogene pool is initiated by a small fraction of the egg mitogene pool. However, the characteristics and relationship between them has not yet been investigated. This study quantitatively analyzed the heteroplasmy landscape, genetic loads, and selection strength of the mitogene pool of egg and hatchling in the silver carp (Hypophthalmichthys molitrix) using high-throughput resequencing. The results showed heteroplasmic sites distribute across the whole mitogenome in both eggs and hatchlings. The dominant substitution was Transversion in eggs and Transition in hatching accounting for 95.23%

SUBMITTER: Li J 

PROVIDER: S-EPMC11491513 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature