Modeling the evolution of Schizosaccharomyces pombe populations with multiple killer meiotic drivers.

ABSTRACT: Meiotic drivers are selfish genetic loci that can be transmitted to more than half of the viable gametes produced by a heterozygote. This biased transmission gives meiotic drivers an evolutionary advantage that can allow them to spread over generations until all members of a population carry the driver. This evolutionary power can also be exploited to modify natural populations using synthetic drivers known as "gene drives." Recently, it has become clear that natural drivers can spread within genomes to birth multicopy gene families. To understand intragenomic spread of drivers, we model the evolution of 2 or more distinct meiotic drivers in a population. We employ the wtf killer meiotic drivers from Schizosaccharomyces pombe, which are multicopy in all sequenced isolates, as models. We fi

SUBMITTER: Lopez Hernandez JF 

PROVIDER: S-EPMC11491527 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature