Serum Transaminases and Older Adults: Distribution and Associations With All-Cause Mortality.

ABSTRACT:

Background

Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are commonly ordered tests in general medical practice. However, their distribution and significance in older adults are understudied. As such, we aimed to evaluate sex-stratified distribution of both ALT and AST in older adults (≥70 years) and assess for associations with mortality.

Methods

Post-hoc analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) randomized, placebo-controlled trial of daily low-dose aspirin for initially relatively healthy older persons. Univariate analysis and multiple logistic regression were used to explore baseline characteristics. Cox regression and restricted cubic splines were used to examine links between transaminase levels and mortality.

Results</

SUBMITTER: Clayton-Chubb D 

PROVIDER: S-EPMC11491531 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature