Agricultural paraquat dichloride use and Parkinson's disease in California's Central Valley.

ABSTRACT:

Background

Paraquat dichloride is currently among the most widely used commercial herbicides in the USA. In the present study, we provide epidemiological assessment of ambient paraquat exposure and Parkinson's disease (PD) risk in a population-based study of PD in agricultural regions of Central California.

Methods

Based on 829 PD patients and 824 community controls, we assessed associations between ambient paraquat dichloride exposure and PD. We estimated residential and workplace proximity to commercial agricultural applications in three California counties since 1974 using the CA pesticide use reporting (PUR) data and land use maps. We evaluated any, duration and average intensity [pounds (0.45 kilograms) per acre per year] of exposure for paraquat in four time windows.

SUBMITTER: Paul KC 

PROVIDER: S-EPMC11491592 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature