Examining the link between gut microbiota and periodontitis in East Asians using Mendelian randomization.

ABSTRACT:

Objective

This study explores the possible connection between periodontitis and gut microbiota in East Asians, a relationship that has been largely unexplored until now.

Methods

Using publicly available genome-wide association study (GWAS) data, we performed Mendelian randomization (MR). We analyzed GWAS summary statistics to assess if gut microbiota could causally influence periodontitis risk. We applied methods such as MR-Egger, weighted median, inverse variance weighting, and simple MR, and conducted sensitivity analyses to confirm our findings.

Results

Utilizing the Inverse-Variance Weighted approach, we identified potential causal relationships between 17 host-genetically influenced gut microbiota characteristics and periodontitis, including Granulicatella adi

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11491689 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature