Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood.

ABSTRACT:

Background

In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.

Objectives

To assess the impact of protein level variations on simulated thrombin generation in normal and factor (F)VIII-, FIX-, or FXI-deficient blood.

Methods

We used a mathematical model of flow-mediated coagulation to simulate thrombin generation with all possible combinations of clotting protein variations within the normal range and for various tissue factor levels. We selected, analyzed, and ranked combinations that enhanced thrombin generation compared with baseline.

Results

Protein variations most strongly affected thrombin generation at intermediate tis

SUBMITTER: Stobb MT 

PROVIDER: S-EPMC11491717 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature