Overexpression of <i>Kdm6b</i> induces testicular differentiation in a temperature-dependent sex determination system.

ABSTRACT: In reptiles, such as the red-eared slider turtle ( Trachemys scripta elegans), gonadal sex determination is highly dependent on the environmental temperature during embryonic stages. This complex process, which leads to differentiation into either testes or ovaries, is governed by the finely tuned expression of upstream genes, notably the testis-promoting gene Dmrt1 and the ovary-promoting gene Foxl2. Recent studies have identified epigenetic regulation as a crucial factor in testis development, with the H3K27me3 demethylase KDM6B being essential for Dmrt1 expression in T. s. elegans. However, whether KDM6B alone can induce testicular differentiation remains unclear. In this study, we found that overexpression of Kdm6b in T. s. elegans embry

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11491778 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature