PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality.

ABSTRACT: Serine protease 50 (PRSS50/TSP50) is highly expressed in spermatocytes. Our study investigated its role in testicular development and spermatogenesis. Initially, PRSS50 knockdown was observed to impair DNA synthesis in spermatocytes. To further explore this, we generated PRSS50 knockout ( Prss50 ^-/- ) mice ( Mus musculus), which exhibited abnormal spermatid nuclear compression and reduced male fertility. Furthermore, dysplastic seminiferous tubules and decreased sex hormones were observed in 4-week-old Prss50 ^-/- mice, accompanied by meiotic progression defects and increased apoptosis of spermatogenic cells. Mechanistic analysis indicated that PRSS50 deletion resulted in increased phosphorylation of extracellular signal-regulated pro

SUBMITTER: Niu CX 

PROVIDER: S-EPMC11491780 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature