Maternal factors for neural tube defects in offspring: An umbrella review.

ABSTRACT:

Objective

We conducted an umbrella review focusing on maternal risk factors during pregnancy associated with neural tube defects (NTDs).

Methods

Our search was in databases PubMed, Scopus, and Web of Science. We specifically targeted meta-analyses examining maternal factors during pregnancy in relation to NTDs. The comparison involved assessing metrics such as odds ratio (OR) or related risk ratios reported in the included studies, as well as parameters like heterogeneity (I²), 95% prediction interval, small-study effects, excess significance biases, and sensitivity analysis.

Results

Three risk factors for fetal NTDs, namely hyperthermia with an OR of 1.92, obesity with an OR of 1.68, and passive smoking with an OR of 1.90, were classified as highly suggestive

SUBMITTER: Arabzadeh H 

PROVIDER: S-EPMC11491881 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature