Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting.

ABSTRACT:

Background

Manual white blood cell (WBC) differential counts as a predictor for neonatal sepsis development in a low-resource setting have not been thoroughly evaluated. We hypothesized that manual differentiation (specifically immature:total [I:T] neutrophil ratios) would be feasible and useful as an adjunct to predict early-onset neonatal sepsis (EONS). Secondarily, we hypothesized that vaccination with bacillus Calmette-Guérin (BCG) and oral polio vaccine (OPV) could alter WBC differential counts and thus might reduce its predictive performance.

Methods

We performed a prospective cohort study within a randomized trial, randomizing healthy, high-risk newborns admitted to the nursery at the national hospital in Guinea-Bissau 1:1 to BCG+OPV at admission or at discharge (usua

SUBMITTER: Golding CN 

PROVIDER: S-EPMC11491923 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature