Distinct and Overlapping Metabolites Associated with Visual Impairment and Cognitive Impairment.

ABSTRACT:

Background

Previous studies found that visual impairment (VI) is associated with higher risk of cognitive impairment, but the molecular basis of these conditions is unknown.

Objective

We aim to compare the metabolite associations of VI and cognitive impairment.

Methods

The study population with comprehensive measurements was derived from the UK Biobank study. Visual acuity worse than 0.3 logMAR units were defined as VI. Failure in one or more of the four cognitive tests was defined as cognitive impairment. A panel of 249 metabolites was measured using a nuclear magnetic resonance metabolites profiling platform. Logistic regression models were applied to compare metabolite associations with VI and cognitive impairment.

Results

23,775 participants with complete d

SUBMITTER: Hu W 

PROVIDER: S-EPMC11491940 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature